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A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence.
- Source :
-
Schizophrenia research [Schizophr Res] 2014 Jan; Vol. 152 (1), pp. 139-45. Date of Electronic Publication: 2013 Nov 22. - Publication Year :
- 2014
-
Abstract
- Objective: Schizophrenia is associated with atopy and increased inflammatory markers. We report a population-based longitudinal study of the associations between childhood atopic disorders, subsequent serum inflammatory markers, interleukin 6 (IL-6) and C-reactive protein (CRP), and the risk of psychotic experiences (PEs).<br />Method: PEs were assessed at age 13 years (n=6785). Presence of clinician-diagnosed atopic disorders (asthma and eczema) was determined from parent-completed questionnaires at age 10 years (n=7814). Serum IL-6 and CRP were measured at age 9 years (n=5076). Logistic regression examined the association between (1) atopy and PEs, (2) inflammatory markers and PEs, and (3) mediating effects of inflammatory markers on the atopy-PEs association. Linear regression examined the association between atopy and inflammatory markers. Age, gender, social class, ethnicity and body mass index were included as potential confounders.<br />Results: At age 10 years, about 14% of the sample was reported to have asthma, 12% eczema, and 7% both asthma and eczema. Compared with children with no atopy, risk of PEs at age 13 years was increased for all of these groups; adjusted odds ratios (95% CI) were, respectively, 1.39 (1.10-1.77), 1.33 (1.04-1.69), and 1.44 (1.06-1.94). Atopy was associated with increased serum IL-6 and CRP; however, this did not mediate association between atopy and PEs. Inflammatory markers were not associated with later PEs.<br />Conclusion: Childhood atopic disorders increase the risk of psychotic experiences in adolescence. Follow-up of these individuals will be useful to determine the effect of atopy and inflammation on different trajectories of early-life PEs.<br /> (© 2013. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Asthma complications
Asthma diagnosis
Asthma epidemiology
Child
Community Health Planning
Disease Progression
Eczema blood
Eczema complications
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Psychiatric Status Rating Scales
Surveys and Questionnaires
C-Reactive Protein metabolism
Eczema epidemiology
Interleukin-6 blood
Psychotic Disorders blood
Psychotic Disorders epidemiology
Psychotic Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2509
- Volume :
- 152
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 24268471
- Full Text :
- https://doi.org/10.1016/j.schres.2013.09.021