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Azathioprine induced serious portal hypertension: a case series of three IBD patients and review of the literature.
- Source :
-
Acta gastro-enterologica Belgica [Acta Gastroenterol Belg] 2013 Sep; Vol. 76 (3), pp. 342-6. - Publication Year :
- 2013
-
Abstract
- We report 3 male IBD patients (2 Crohn's Disease, 1 Ulcerative Colitis) developing thrombocytopenia and splenomegaly on azathioprine treatment. All patients were diagnosed with significant portal hypertension due to histological proven nodular regenerative hyperplasia (NRH) of the liver. In two of three patients, liver function tests remained completely normal. In addition we provide a short literature review of azathioprine induced NRH covering etiology, imaging, pathology, prognosis and treatment.
- Subjects :
- Adult
Azathioprine therapeutic use
Humans
Hypertension, Portal physiopathology
Immunosuppressive Agents adverse effects
Immunosuppressive Agents therapeutic use
Male
Portal Pressure drug effects
Azathioprine adverse effects
Hypertension, Portal chemically induced
Inflammatory Bowel Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1784-3227
- Volume :
- 76
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta gastro-enterologica Belgica
- Publication Type :
- Academic Journal
- Accession number :
- 24261031