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Facile solvothermal synthesis of mesostructured Fe3O4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents.
- Source :
-
Chemistry, an Asian journal [Chem Asian J] 2014 Feb; Vol. 9 (2), pp. 546-53. Date of Electronic Publication: 2013 Nov 20. - Publication Year :
- 2014
-
Abstract
- We report a facile fabrication of a host-metal-guest coordination-bonding system in a mesostructured Fe3O4/chitosan nanoparticle that can act as a pH-responsive drug-delivery system. The mesostructured Fe3O4/chitosan was synthesized by a solvothermal approach with iron(III) chloride hexahydrate as a precursor, ethylene glycol as a reducing agent, ammonium acetate as a porogen, and chitosan as a surface-modification agent. Subsequently, doxorubicin (DOX), acting as a model drug (guest), was loaded onto the mesostructured Fe3O4/chitosan nanoparticles, with chitosan acting as a host molecule to form the NH2-Zn(II)-DOX coordination architecture. The release of DOX can be achieved through the cleavage of coordination bonds that are sensitive to variations in external pH under weakly acidic conditions. The pH-responsive nature of the nanoparticles was confirmed by in vitro releases and cell assay tests. Furthermore, the relaxation efficiency of the nanoparticles as high-performance magnetic resonance imaging contrast agents was also investigated. Experimental results confirm that the synthesized mesostructured Fe3O4/chitosan is a smart nanovehicle for drug delivery owing to both its pH-responsive nature and relaxation efficiency.<br /> (Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antibiotics, Antineoplastic chemistry
Antibiotics, Antineoplastic toxicity
Cell Survival drug effects
Contrast Media chemistry
Contrast Media metabolism
Doxorubicin chemistry
Doxorubicin toxicity
Drug Carriers chemical synthesis
HeLa Cells
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Imaging
Porosity
Zinc chemistry
Chitosan chemistry
Drug Carriers chemistry
Ferrosoferric Oxide chemistry
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1861-471X
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chemistry, an Asian journal
- Publication Type :
- Academic Journal
- Accession number :
- 24259489
- Full Text :
- https://doi.org/10.1002/asia.201301072