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Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders.
- Source :
-
European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2014 Aug; Vol. 264 (5), pp. 459-63. Date of Electronic Publication: 2013 Nov 20. - Publication Year :
- 2014
-
Abstract
- Borderline personality (BPD) and complex posttraumatic stress disorders (PTSD) are both powerfully associated with the experience of interpersonal violence during childhood and adolescence. The disorders frequently co-occur and often result in pervasive problems in, e.g., emotion regulation and altered pain perception, where the endocannabinoid system is deeply involved. We hypothesize an endocannabinoid role in both disorders. We investigated serum levels of the endocannabinoids anandamide and 2-arachidonoylglycerol and related fatty acid ethanolamides (FAEs) in BPD, PTSD, and controls. Significant alterations were found for both endocannabinoids in BPD and for the FAE oleoylethanolamide in PTSD suggesting a respective link to both disorders.
- Subjects :
- Adult
Amides
Arachidonic Acids blood
Endocannabinoids blood
Ethanolamines blood
Female
Glycerides blood
Humans
Male
Middle Aged
Palmitic Acids blood
Polyunsaturated Alkamides blood
Prospective Studies
Psychiatric Status Rating Scales
Severity of Illness Index
Young Adult
Borderline Personality Disorder blood
Fatty Acids blood
Stress Disorders, Post-Traumatic blood
Subjects
Details
- Language :
- English
- ISSN :
- 1433-8491
- Volume :
- 264
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European archives of psychiatry and clinical neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 24253425
- Full Text :
- https://doi.org/10.1007/s00406-013-0470-8