Back to Search
Start Over
Evaluation of the effect of comorbidity on survival in pancreatic cancer by using "Charlson Comorbidity Index" and "Cumulative Illness Rating Scale".
- Source :
-
Wiener klinische Wochenschrift [Wien Klin Wochenschr] 2014 Jan; Vol. 126 (1-2), pp. 36-41. Date of Electronic Publication: 2013 Nov 19. - Publication Year :
- 2014
-
Abstract
- Background: Effect of comorbidity on the treatments that patients receive is not clear, as healthy elderly patients and the elderly with less comorbid diseases are included in the studies. In the present study, the effect of comorbidity on the survival was evaluated using Charlson Comorbidity Index (CCI) and Cumulative Illness Rating Scale (CIRS).<br />Material and Method: The general features and comorbid diseases of the pancreatic cancer patients were retrospectively screened from the patient files using the automated system. CCI and CIRS were used as the comorbidity indices.<br />Results: A total of 106 patients with pancreatic cancer were included in the study. The median overall survival rate was 9.0 [95 % confidence interval (CI): 6.7-11.3] months. The median overall survival rate was found as 9.4 (95 % CI: 6.7-12.1) months in the patients whose CCI score was ≤ 2 and was found as 6.2 (95 % CI: 4.0-8.3) months in the patients with CCI scores ≥ 3 (p = 0.05). The median overall survival rate was calculated as 9.8 (95 % CI: 6.3-13.4) months in the patients with CIRS scores ≤ 2 and was calculated as 8.3 (95 % CI: 6.0-10.6) months in the patients with CIRS scores ≥ 3 (p = 0.51). When surgery, radiotherapy, grading, and CCI score were evaluated using multivariate analysis, it was observed that only the treatment modality had a significant effect on the survival rate.<br />Conclusion: The results on the use of comorbidity indices are contradictory for the cancers with lower survival rates such as pancreatic cancer. New prognostic scales might be developed for this patient group by considering the side effects of chemotherapy.
- Subjects :
- Adult
Aged
Aged, 80 and over
Comorbidity
Humans
Incidence
Middle Aged
Pancreatic Neoplasms diagnosis
Pancreatic Neoplasms therapy
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment methods
Turkey epidemiology
Cardiovascular Diseases mortality
Diabetes Complications mortality
Digestive System Diseases mortality
Neoplasms, Multiple Primary mortality
Pancreatic Neoplasms mortality
Severity of Illness Index
Survival
Subjects
Details
- Language :
- English
- ISSN :
- 1613-7671
- Volume :
- 126
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Wiener klinische Wochenschrift
- Publication Type :
- Academic Journal
- Accession number :
- 24249323
- Full Text :
- https://doi.org/10.1007/s00508-013-0453-9