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Dual-energy computed tomography in the assessment of vascular and parenchymal enhancement in suspected pulmonary hypertension.
- Source :
-
Journal of thoracic imaging [J Thorac Imaging] 2014 Mar; Vol. 29 (2), pp. 98-106. - Publication Year :
- 2014
-
Abstract
- Purpose: To evaluate quantitative differences in central pulmonary artery (PA) and pulmonary global and regional enhancement in patients with and without pulmonary hypertension (PH) using dual-energy computed tomography (DECT).<br />Materials and Methods: We retrospectively studied 391 thoracic DECT studies and identified 89 patients with PA pressure (PAP) data and a pulmonary angiogram. PH was defined as a mean PAP of ≥25 mm Hg on right heart catheterization (RHC) (n=19) or a systolic PAP of ≥40 mm Hg on echocardiography (n=20). PH absence was defined by entirely normal echocardiography or RHC (n=50). PA enhancement (PAenh) was calculated from DECT iodine images. Volumetric enhancement of each whole lung (WLenh), 6 standard lung regions (RLenh), and 24 two-dimensional standardized regions of interest (ROIenh) was performed in each patient using pulmonary blood volume analysis.<br />Results: Mean PAenh was greater in PH patients compared with controls (272 vs. 252 HU, P<0.05), with a reciprocal reduction in mean WLenh (27 vs. 32 HU, P<0.01). Mean ROIenh (n=2058) confirmed lower parenchymal enhancement in PH (27 vs. 32 HU, P<0.001), with greater mean ROIenh standard deviation (10.5 vs. 9.3, P<0.001). Mean intrapatient pulmonary enhancement variability was greater in PH patients than in controls for 6 RLenh (variance 37 vs. 22, P=0.02) and 24 ROIenh measures (variance 188 vs. 130, P=0.04). RLenh and ROIenh variance correlated with RHC pulmonary vascular resistance (PVR) (r=0.44, 0.48; P=0.04, 0.03, respectively). A ratio of PAenh/WLenh distinguished PH from non-PH patients (10.9 vs. 8.4, P<0.001) and correlated best with PVR (r=0.59, P=0.004).<br />Conclusions: PH patients demonstrate increased PAenh with a reciprocal reduction and greater variation in parenchymal enhancement; a DECT ratio of central to parenchymal enhancement correlates with PVR and may help identify PH.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Image Processing, Computer-Assisted methods
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
Ultrasonography
Vascular Resistance physiology
Vena Cava, Inferior diagnostic imaging
Hypertension, Pulmonary diagnostic imaging
Pulmonary Artery diagnostic imaging
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1536-0237
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of thoracic imaging
- Publication Type :
- Academic Journal
- Accession number :
- 24247086
- Full Text :
- https://doi.org/10.1097/RTI.0000000000000061