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Demyelinating disease in SLE: is it multiple sclerosis or lupus?
- Source :
-
Best practice & research. Clinical rheumatology [Best Pract Res Clin Rheumatol] 2013 Jun; Vol. 27 (3), pp. 405-24. - Publication Year :
- 2013
-
Abstract
- Among the 12 systemic lupus erythematosus (SLE)-related central nervous system (CNS) syndromes defined by the American College of Rheumatology (ACR), demyelinating syndrome and myelopathy are two of the less prevalent and more poorly understood ones. One important issue concerning demyelinating disease in SLE is that it can be easily misdiagnosed with other central nervous system demyelinating disorders such as multiple sclerosis (MS). A clinically isolated neurological syndrome can be the presenting feature before other concomitant symptoms of SLE appear or definite MS is diagnosed. Although challenging, some diagnostic tests used in clinical practice and research may help to differentiate between these entities. These tests have improved the understanding of the pathogenesis in these diseases, but some points, such as the role of antiphospholipid antibodies in SLE-associated transverse myelitis, remain unclear and are a matter of ongoing debate. This review discusses clinical, pathophysiological, radiological and therapeutic concepts of demyelinating disease of the CNS in SLE, focussing on its differentiation from MS and its relation with other CNS demyelinating processes, such as transverse myelitis, optic neuritis and neuromyelitis optica.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antibodies, Antiphospholipid blood
Demyelinating Autoimmune Diseases, CNS diagnosis
Demyelinating Autoimmune Diseases, CNS therapy
Humans
Lupus Erythematosus, Systemic diagnosis
Lupus Erythematosus, Systemic therapy
Multiple Sclerosis diagnosis
Multiple Sclerosis therapy
Demyelinating Autoimmune Diseases, CNS etiology
Lupus Erythematosus, Systemic complications
Multiple Sclerosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1770
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Best practice & research. Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 24238696
- Full Text :
- https://doi.org/10.1016/j.berh.2013.07.010