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Prostaglandin synthesis in human placenta and fetal membranes.

Authors :
Duchesne MJ
Thaler-Dao H
de Paulet AC
Source :
Prostaglandins [Prostaglandins] 1978 Jan; Vol. 15 (1), pp. 19-42.
Publication Year :
1978

Abstract

The conversion of exogenous arachidonic acid into prostaglandins was studied in human placenta and fetal membrane microsomes. Only one prostaglandin was formed, prostaglandin E2 (PGE2), in fetal membrane microsomes. In placental microsomes PGE2 was further transformed into 15 keto-PGE2. Cofactor requirements and some characteristics of the system were studied. 1 to 3% conversion of arachidonic acid into prostaglandins was observed in placental microsomes and 5 to 8% conversion in fetal membrane microsomes.

Subjects

Subjects :
Arachidonic Acids metabolism
Borohydrides pharmacology
Chromatography, Thin Layer
Female
Humans
Hydrochloric Acid pharmacology
Hydrogen-Ion Concentration
Hydroxyprostaglandin Dehydrogenases pharmacology
Microsomes metabolism
Oxidation-Reduction
Pregnancy
Prostaglandin-Endoperoxide Synthases metabolism
Prostaglandins analysis
Prostaglandins E analysis
Prostaglandins E biosynthesis
Time Factors
Extraembryonic Membranes metabolism
Placenta metabolism
Prostaglandins biosynthesis

Details

Language :
English
ISSN :
0090-6980
Volume :
15
Issue :
1
Database :
MEDLINE
Journal :
Prostaglandins
Publication Type :
Academic Journal
Accession number :
24235
Full Text :
https://doi.org/10.1016/s0090-6980(78)80003-3
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