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The -174G/C and -572G/C interleukin 6 promoter gene polymorphisms in mexican patients with rheumatoid arthritis: a case-control study.
- Source :
-
Clinical & developmental immunology [Clin Dev Immunol] 2013; Vol. 2013, pp. 959084. Date of Electronic Publication: 2013 Sep 23. - Publication Year :
- 2013
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Abstract
- Objective: There is a lack of information about the genotype frequencies of IL-6 -174G/C and -572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the association of the IL-6 -174G/C and -572G/C polymorphisms in Mexican mestizo with RA.<br />Methods: We included 137 patients with RA and 102 healthy controls. Patients were assessed for clinical characteristics. IL-6 -174G/C and -572G/C polymorphisms were genotyped using PCR-RFLP analysis. Allele and genotype frequencies and the Hardy-Weinberg equilibrium were computed. Odds ratios (ORs) were computed to identify the risk for RA associated with the presence of GG genotype in comparison with the GC or CC genotypes.<br />Results: The genotype -174GG occurred at a higher frequency in cases and controls (77.4% versus 78.4%, P = 0.845). We found similar results for the genotype -572GG (54% in patients versus 60.8% in controls, P = 0.295).<br />Conclusions: This is the first study to evaluate the association of -174G/C and -572G/C polymorphisms of the IL-6 gene with RA in Mexican mestizo patients. These two polymorphisms were not associated with RA in the studied sample. Additional studies are required to evaluate if these IL-6 polymorphisms have relevance to the development of more severe disease.
Details
- Language :
- English
- ISSN :
- 1740-2530
- Volume :
- 2013
- Database :
- MEDLINE
- Journal :
- Clinical & developmental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 24223608
- Full Text :
- https://doi.org/10.1155/2013/959084