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Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Dec 06; Vol. 442 (1-2), pp. 16-21. Date of Electronic Publication: 2013 Nov 06. - Publication Year :
- 2013
-
Abstract
- Neural stem cells continuously generate new neurons in the ventricular-subventricular zone (V-SVZ) of the postnatal and adult mammalian brain. New neurons born in the rodent V-SVZ migrate toward the olfactory bulb (OB), where they differentiate into interneurons. To reveal novel intracellular molecular mechanisms that control postnatal neuronal migration, we performed a global proteomic search for proteins interacting with Girdin, an essential protein for postnatal neuronal migration. Using GST pull-down and LC-MS/MS shotgun analysis, we identified cytoskeletal proteins, cytoskeleton-binding proteins, and signal-transduction proteins as possible participants in neuronal migration. Our results suggest that Girdin and Girdin-interacting proteins control neuronal migration by regulating actin and/or microtubule dynamics.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Brain cytology
Cytoskeletal Proteins metabolism
Mice
Mice, Inbred ICR
Neural Stem Cells cytology
Neurons cytology
Proteomics
Rats
Rats, Wistar
Brain growth & development
Cell Movement
Microfilament Proteins metabolism
Neural Stem Cells physiology
Neurogenesis
Neurons physiology
Vesicular Transport Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 442
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 24211587
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.10.126