A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing.

Authors :: Sangal V
Burkovski A
Hunt AC
Edwards B
Blom J
Hoskisson PA
Source :: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2014 Jan; Vol. 21, pp. 54-7. Date of Electronic Publication: 2013 Nov 05.
Publication Year :: 2014
Abstract: The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)

Subjects :: Genomics
Pharynx microbiology
Phylogeny
Sequence Analysis, DNA
Corynebacterium diphtheriae classification
Corynebacterium diphtheriae genetics
Genome, Bacterial

Language :: English
ISSN :: 1567-7257
Volume :: 21
Database :: MEDLINE
Journal :: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Publication Type :: Academic Journal
Accession number :: 24200588
Full Text :: https://doi.org/10.1016/j.meegid.2013.10.019

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