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Major histocompatibility complex I in brain development and schizophrenia.
- Source :
-
Biological psychiatry [Biol Psychiatry] 2014 Feb 15; Vol. 75 (4), pp. 262-8. Date of Electronic Publication: 2013 Oct 10. - Publication Year :
- 2014
-
Abstract
- Although the etiology of schizophrenia (SZ) remains unknown, it is increasingly clear that immune dysregulation plays a central role. Genome-wide association studies reproducibly indicate an association of SZ with immune genes within the major histocompatibility complex (MHC). Moreover, environmental factors that increase risk for SZ, such as maternal infection, alter peripheral immune responses as well as the expression of immune molecules in the brain. MHC class I (MHCI) molecules might mediate both genetic and environmental contributions to SZ through direct effects on brain development in addition to mediating immunity. MHCI molecules are expressed on neurons in the central nervous system throughout development and into adulthood, where they regulate many aspects of brain development, including neurite outgrowth, synapse formation and function, long-term and homeostatic plasticity, and activity-dependent synaptic refinement. This review summarizes our current understanding of MHCI expression and function in the developing brain as well as its involvement in maternal immune activation, from the perspective of how these roles for MHCI molecules might contribute to the pathogenesis of SZ.<br /> (© 2013 Society of Biological Psychiatry Published by Society of Biological Psychiatry All rights reserved.)
- Subjects :
- Animals
Humans
Neurogenesis immunology
Neurogenesis physiology
Neurons physiology
Risk Factors
Schizophrenia epidemiology
Synapses immunology
Synapses physiology
Brain growth & development
Brain immunology
Major Histocompatibility Complex physiology
Neurons immunology
Schizophrenia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2402
- Volume :
- 75
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 24199663
- Full Text :
- https://doi.org/10.1016/j.biopsych.2013.10.003