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Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1985 Dec 17; Vol. 119 (3), pp. 153-67. - Publication Year :
- 1985
-
Abstract
- Electrophysiological and pharmacological studies have shown that peripheral-type benzodiazepine receptors modulate voltage-sensitive calcium channels in the heart. We have compared these binding sites with binding sites for [3H]dihydropyridines, which are believed to label such channels. Although no direct or allosteric interaction could be demonstrated between the two sites, their subcellular distribution--sarcolemma and ryanodine-sensitive sarcoplasmic reticulum--was parallel. Size determination of the two sites suggests that the receptors for these two classes of compounds are separate molecules packaged in the same membrane compartment.
- Subjects :
- Animals
Benzodiazepinones metabolism
Benzodiazepinones pharmacology
Binding Sites
Calcium metabolism
Calcium Channels
Cell Fractionation
Dogs
Ion Channels
Isoquinolines metabolism
Isoquinolines pharmacology
Isradipine
Male
Molecular Weight
Myocardium metabolism
Nifedipine analogs & derivatives
Nifedipine metabolism
Nifedipine pharmacology
Nitrendipine
Oxadiazoles metabolism
Rats
Rats, Inbred Strains
Verapamil metabolism
Verapamil pharmacology
Calcium Channel Blockers metabolism
Myocardium ultrastructure
Receptors, GABA-A metabolism
Receptors, Nicotinic metabolism
Sarcolemma metabolism
Sarcoplasmic Reticulum metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 119
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2419140
- Full Text :
- https://doi.org/10.1016/0014-2999(85)90291-2