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Delayed anti-CD3 therapy in a mouse heart transplant model induced tolerance and long-term survival of allograft: achieving tolerance.
- Source :
-
Immunotherapy [Immunotherapy] 2013 Nov; Vol. 5 (11), pp. 1173-6. - Publication Year :
- 2013
-
Abstract
- Goto R, You S, Zaitsu M, Chatenoud L, Wood KJ. Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3(+) CD4(+) graft infiltrating cells. Am. J. Transplant. 13(7), 1655-1664 (2013). Humanized Fc receptor nonbinding anti-CD3 monoclonal antibodies have been tested in patients with autoimmune diseases with the goal of inducing immune tolerance. However, the timing of drug administration may be an important determinant of the biologic effects, since not all T cells are equally affected, and there may be different subsets of cells involved during the evolution of immune responses. The study by Goto et al. showed that delayed administration of anti-CD3 therapy was more effective in depleting alloreactive T cells than administration at the time of transplant, and resulted in long-term survival of the graft by promoting infiltration of CD4 Tregs into the graft.
- Subjects :
- Animals
Female
Male
Antibodies, Monoclonal, Humanized therapeutic use
CD3 Complex drug effects
CD4-Positive T-Lymphocytes immunology
Forkhead Transcription Factors immunology
Graft Rejection prevention & control
Graft Survival drug effects
Heart Transplantation immunology
Repressor Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1750-7448
- Volume :
- 5
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 24188671
- Full Text :
- https://doi.org/10.2217/imt.13.113