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Hypotonic solution decreases serum sodium in infants with moderate bronchiolitis.
- Source :
-
Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2014 Mar; Vol. 103 (3), pp. e111-5. Date of Electronic Publication: 2013 Dec 20. - Publication Year :
- 2014
-
Abstract
- Aim: To investigate the influence of hypotonic parenteral hydration on serum and urinary sodium and osmolality in infants with moderate bronchiolitis.<br />Methods: We studied 36 infants (mean age 3.7 ± 2.3 months), with a diagnosis of moderate bronchiolitis admitted to a paediatric emergency unit in São Paulo, Brazil. Patients received a standard parenteral hypotonic solution, according to Holliday and Segar, during the first 24 h, due to respiratory distress. The disease was monitored by a respiratory severity score (RDAI-Respiratory Distress Assessment Instrument), respiratory rate and oxygen saturation. Serum and urinary sodium and osmolality were monitored at admission, 24 and 48 h after admission.<br />Results: All respiratory parameters improved during hospitalisation. Serum sodium and osmolality dropped after 24 h (136.8 ± 2.8 and 135.8 ± 2.6 mEq/L, p = 0.031; 283.4 ± 4.1 and 281.6 ± 3.9 mOsm/kg, p = 0.004 respectively) as well as urinary osmolality (486.8 ± 243.4 mOsm/kg and 355.7 ± 205.0 mOsm/kg, p < 0.001) when compared to admission.<br />Conclusion: This study reinforces the occurrence of hyponatraemia in bronchiolitis even in patients with moderate disease and highlights the risk of serum sodium drop caused by hypotonic parenteral hydration.<br /> (©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
- Subjects :
- Brazil epidemiology
Bronchiolitis blood
Bronchiolitis urine
Cohort Studies
Disease Progression
Emergency Medical Services
Female
Humans
Hyponatremia epidemiology
Hyponatremia etiology
Incidence
Infant, Newborn
Infusions, Intravenous
Male
Prospective Studies
Bronchiolitis complications
Hyponatremia prevention & control
Hypotonic Solutions therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2227
- Volume :
- 103
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta paediatrica (Oslo, Norway : 1992)
- Publication Type :
- Academic Journal
- Accession number :
- 24188330
- Full Text :
- https://doi.org/10.1111/apa.12493