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Safety of very early sheath removal in patients treated with REG1 for acute coronary syndromes: insights from the RADAR trial.
- Source :
-
The Journal of invasive cardiology [J Invasive Cardiol] 2013 Nov; Vol. 25 (11), pp. 593-9. - Publication Year :
- 2013
-
Abstract
- Background: RADAR compared REG1 (25%, 50%, 75%, 100% reversal) with unfractionated heparin (UFH) in 640 acute coronary syndrome (ACS) patients (479 REG1 patients, 161 UFH patients) undergoing an invasive management strategy. We sought to determine whether the REG1 anticoagulation system allows for safer early arterial sheath removal following cardiac catheterization.<br />Methods: REG1 patients had arterial sheath removal immediately post catheterization. We measured arterial sheath management outcomes and vascular access complications in patients who had sheath removal without vascular closure device implantation; 461 patients were included (349 REG1 patients, 112 UFH patients).<br />Results: The median (25th, 75th) time from end of catheterization to arterial sheath removal was shorter in REG1 arms regardless of reversal strategy (26 minutes [18, 46]) compared with UFH (210 minutes [102, 342]). There was no increase in median time from sheath removal to hemostasis (10 minutes [10, 20] and 10 minutes [10, 20]; P=.60); vascular access-site bleeding complications were numerically fewer with REG1 than UFH (6% vs 11%; odds ratio [OR], 0.57; 95% CI, 0.27-1.18; P=.14). There were no differences in time to ambulation or hospital length of stay between the groups.<br />Conclusions: REG1 allows for very early arterial sheath removal following cardiac catheterization without increasing the time to hemostasis or vascular access-site bleeding complications. Further studies are needed to determine whether anticoagulation with REG1 will translate into shorter hospital lengths of stay and reduced costs in ACS patients.
- Subjects :
- Acute Coronary Syndrome blood
Acute Coronary Syndrome diagnostic imaging
Aged
Anticoagulants administration & dosage
Cardiac Catheterization adverse effects
Device Removal adverse effects
Female
Follow-Up Studies
Heparin administration & dosage
Humans
Male
Middle Aged
Percutaneous Coronary Intervention adverse effects
Postoperative Hemorrhage etiology
Radiography
Single-Blind Method
Thrombosis prevention & control
Time Factors
Treatment Outcome
Acute Coronary Syndrome surgery
Cardiac Catheterization instrumentation
Device Removal methods
Percutaneous Coronary Intervention instrumentation
Postoperative Hemorrhage prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1557-2501
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of invasive cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 24184894