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Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice.
- Source :
-
Nutrition research (New York, N.Y.) [Nutr Res] 2013 Nov; Vol. 33 (11), pp. 942-51. Date of Electronic Publication: 2013 Sep 17. - Publication Year :
- 2013
-
Abstract
- Type 1 diabetes is an endocrinologic disorder characterized by uncontrolled glucose regulation and oxidative stress. Olive leaves have been studied extensively for their antioxidant activity and capacity to improve immune function. We hypothesized that olive leaf powder supplementation will be effective in inhibiting the oxidative stress and immune dysregulation in streptozotocin (STZ)-induced diabetic mice. Mice were assigned to 1 of 5 groups: control (C), STZ-induced diabetes (D), and STZ-induced diabetes supplemented with very low dose (VLOL), low dose (LOL), or high dose of olive leaf powder (HOL). Blood glucose in the VLOL and LOL groups was lower than that in the D group (P < .05). Insulin levels were increased in all experimental groups in comparison with that in the D group, (P < .05). Superoxide dismutase, glutathione peroxidase, and catalase activities were shown to decrease in the D group, whereas these were increased in the VLOL and LOL groups. Nitric oxide levels decreased in the VLOL and LOL groups, as compared with the D group. The messenger RNA expression levels of inducible nitric oxide synthase were significantly decreased in the VLOL and HOL groups, and interferon-γ levels were significantly decreased in the liver of the VLOL, LOL, and HOL groups compared with the levels in the D group. Interleukin-17 levels were significantly decreased in the VLOL and HOL groups. Th1 and Th17 cytokine levels were increased in the D group but decreased in all the experimental groups. Th2 cytokine levels were increased in all olive leaf-supplemented groups compared with those in the D group. These results indicate a reduction in the levels of proinflammatory cytokines, suggesting that olive leaves have the potential to provide therapeutic inhibition of diabetic complications.<br /> (© 2013.)
- Subjects :
- Animals
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Antioxidants metabolism
Antioxidants pharmacology
Antioxidants therapeutic use
Diabetes Mellitus, Experimental immunology
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Type 1 drug therapy
Diabetes Mellitus, Type 1 immunology
Diabetes Mellitus, Type 1 metabolism
Dietary Supplements
Down-Regulation
Male
Mice
Mice, Inbred Strains
Nitric Oxide blood
Nitric Oxide Synthase Type II genetics
Nitric Oxide Synthase Type II metabolism
Plant Leaves
Plant Preparations pharmacology
Plant Preparations therapeutic use
RNA, Messenger metabolism
Cytokines metabolism
Diabetes Mellitus, Experimental drug therapy
Inflammation Mediators metabolism
Olea
Oxidative Stress drug effects
Phytotherapy
Th2 Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0739
- Volume :
- 33
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nutrition research (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 24176234
- Full Text :
- https://doi.org/10.1016/j.nutres.2013.07.011