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T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1986 Feb 01; Vol. 136 (3), pp. 823-9. - Publication Year :
- 1986
-
Abstract
- B cell-deficient, rabbit anti-mouse IgM-treated mice were compared with normal or normal rabbit immunoglobulin-treated controls in their ability to develop proliferative T cell responses, delayed hypersensitivity, and primary or secondary cytotoxic T cell responses. Immunization with hapten-coupled autologous spleen cells resulted in anti-mu-treated mice generating only marginal T cell responses. This decreased responsiveness was shown to be attributable not to an intrinsic T cell defect or to changes in the ability of macrophages from anti-mu-treated mice to present soluble antigen, but rather to the greatly diminished capacity of B cell-deficient spleen cells to present antigen. The results support the concept that B cells play a significant role in antigen presentation required for T cell activation.
- Subjects :
- Animals
Antibodies, Anti-Idiotypic physiology
Cytotoxicity, Immunologic
Epitopes immunology
Hypersensitivity, Delayed immunology
Immunoglobulin M physiology
Leukocyte Count
Mice
Mice, Inbred BALB C
Rabbits
Rats
Rats, Inbred Lew
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Helper-Inducer immunology
p-Azobenzenearsonate immunology
Antigen-Presenting Cells immunology
B-Lymphocytes immunology
Lymphocyte Activation
Lymphopenia immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 136
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 2416835