Back to Search
Start Over
Effects of lidocaine administration via continuous rate infusion on the minimum alveolar concentration of isoflurane in New Zealand White rabbits (Oryctolagus cuniculus).
- Source :
-
American journal of veterinary research [Am J Vet Res] 2013 Nov; Vol. 74 (11), pp. 1377-84. - Publication Year :
- 2013
-
Abstract
- Objective: To evaluate the effect of a continuous rate infusion (CRI) of lidocaine on the minimum alveolar concentration (MAC) of isoflurane in rabbits.<br />Animals: Five 12-month-old female New Zealand White rabbits (Oryctolagus cuniculus).<br />Procedures: Rabbits were anesthetized with isoflurane. Baseline isoflurane MAC was determined by use of the tail clamp technique. A loading dose of lidocaine (2.0 mg/kg, IV) was administered followed by a CRI of lidocaine at 50 μg/kg/min. After 30 minutes, isoflurane MAC was determined. Another loading dose was administered, and the lidocaine CRI then was increased to 100 μg/kg/min. After 30 minutes, isoflurane MAC was determined again. Plasma samples were obtained for lidocaine analysis after each MAC determination.<br />Results: Baseline isoflurane MAC was 2.09%, which was similar to previously reported values in this species. Lidocaine CRI at 50 and 100 μg/kg/min induced significant reductions in MAC. The 50 μg/kg/min CRI resulted in a mean plasma lidocaine concentration of 0.654 μg/mL and reduction of MAC by 10.5%. The 100 μg/kg/min CRI of lidocaine resulted in a mean plasma concentration of 1.578 μg/mL and reduction of MAC by 21.7%. Lidocaine also induced significant decreases in arterial blood pressure and heart rate. All cardiopulmonary variables were within reference ranges for rabbits anesthetized with inhalation anesthetics. No adverse effects were detected; all rabbits had an uncomplicated recovery from anesthesia.<br />Conclusions and Clinical Relevance: Lidocaine administered as a CRI at 50 and 100 μg/kg/min decreased isoflurane MAC in rabbits. The IV administration of lidocaine may be a useful adjunct in anesthesia of rabbits.
- Subjects :
- Anesthetics, Inhalation administration & dosage
Anesthetics, Local administration & dosage
Anesthetics, Local blood
Animals
Balanced Anesthesia veterinary
Blood Pressure drug effects
Chromatography, Liquid
Cross-Over Studies
Dose-Response Relationship, Drug
Female
Heart Rate drug effects
Infusions, Intravenous veterinary
Isoflurane administration & dosage
Lidocaine administration & dosage
Lidocaine blood
Mass Spectrometry
Rabbits
Anesthetics, Inhalation pharmacokinetics
Anesthetics, Local pharmacology
Balanced Anesthesia methods
Isoflurane pharmacokinetics
Lidocaine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-5681
- Volume :
- 74
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- American journal of veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 24168301
- Full Text :
- https://doi.org/10.2460/ajvr.74.11.1377