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Serum anticardiolipin concentrations in patients with chronic periodontitis following scaling and root planing.
- Source :
-
Journal of periodontology [J Periodontol] 2014 May; Vol. 85 (5), pp. 683-7. Date of Electronic Publication: 2013 Oct 21. - Publication Year :
- 2014
-
Abstract
- Background: Anticardiolipin antibodies (antiCl), present in some patients with autoimmune disease, are associated with thrombosis, fetal loss, and other conditions. A significant proportion of patients with chronic periodontitis (CP) test positive for antiCl, likely because some periodontal pathogens contain antigens homologous to the target antigen of antiCl on the serum protein β-2 glycoprotein-I (β2GPI) and thus can induce antiCl by molecular mimicry. The authors hypothesized that treatment of periodontitis by scaling and root planing (SRP) could therefore decrease serum titers of antiCl in patients with CP.<br />Methods: Thirty patients with CP received complete periodontal examinations at baseline including assessment of probing depth, attachment loss, gingival index, and plaque index. SRP was performed in two sessions at 2-week intervals. Eight weeks later, patients were reexamined. Blood samples were taken at baseline, 2 weeks after the initial therapy appointment, and 8 weeks after the completion of treatment for assessment of immunoglobulin (Ig)G and IgM antiCl levels.<br />Results: All periodontal parameters improved significantly. Consistent with previous observations, five (16.7%) of the 30 patients exhibited elevated levels of IgG or IgM antiCl at baseline. Following treatment, the concentrations of IgG and IgM antiCl remained unchanged for the entire cohort of 30 patients. However, in the five patients with elevated antiCl at baseline, IgM antiCl concentrations decreased significantly (P = 0.0008) owing to therapy, while IgG antiCl did not.<br />Conclusion: The oral microflora is a likely source of antigen inducing antiCl in CP, since IgM antiCl levels can be reduced in the short term with conservative therapy.
- Subjects :
- Adult
Alveolar Bone Loss blood
Alveolar Bone Loss therapy
Chronic Periodontitis blood
Cohort Studies
Dental Plaque Index
Female
Follow-Up Studies
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Male
Middle Aged
Periodontal Attachment Loss blood
Periodontal Attachment Loss therapy
Periodontal Index
Periodontal Pocket blood
Periodontal Pocket therapy
Antibodies, Anticardiolipin blood
Chronic Periodontitis therapy
Dental Scaling methods
Immunologic Factors blood
Root Planing methods
Subjects
Details
- Language :
- English
- ISSN :
- 1943-3670
- Volume :
- 85
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 24144272
- Full Text :
- https://doi.org/10.1902/jop.2013.130408