Targeted topical and combination laser surgery for the treatment of angiofibromas.

Background and Objective: The angiofibromas of Tuberous sclerosis (TS) is well described manifestation. Due to the progressive nature of the skin lesion, a safe and effective technique for treating these disfiguring skin lesions is needed.
Study Design/patients and Methods: We report a targeted topical and combination laser technique for treating the angiofibromas of TS in one patient. This includes treatment with topical sirolimus, pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR).
Results: Improvement in the number and appearance of facial angiofibromas and erythema is noted, without scarring or adverse events.
Conclusion: The technique of targeted therapy with sirolimus with electrosurgery, pulsed dye laser treatment, and AFR represents an innovative, safe therapeutic option for treating facial angiofibromas associated with TS.
(© 2013 Wiley Periodicals, Inc.)