Experimental substantiation for the use of mexidol and 3-hydroxypyridine fumarate in chronic myocardial injury.

Authors :: Zamotaeva MN
Chairkin IN
Inchina VI
Drozdov IA
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Jun; Vol. 155 (2), pp. 212-3.
Publication Year :: 2013
Abstract: We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).

Subjects :: Animals
Antioxidants therapeutic use
Aspartate Aminotransferases blood
Energy Metabolism drug effects
Malondialdehyde blood
Myocytes, Cardiac drug effects
Myocytes, Cardiac metabolism
Platelet Aggregation Inhibitors therapeutic use
Potassium blood
Rats
Heart Failure drug therapy
Picolines therapeutic use
Pyridines therapeutic use

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