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Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study.
- Source :
-
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2014 Jun; Vol. 69 (6), pp. 710-6. Date of Electronic Publication: 2013 Oct 14. - Publication Year :
- 2014
-
Abstract
- Background: Advanced glycation endproducts are biologically active compounds that accumulate in disordered metabolism and normal aging. Carboxymethyl-lysine (CML), a ubiquitous human advanced glycation endproduct, has been associated with age-related conditions and mortality. Our objective was to ascertain the relationship between CML and geriatric outcomes (disability and frailty) in a large cohort of older men and women.<br />Methods: In 1996-1997, serum CML was measured in 3,373 Cardiovascular Health Study participants (mean age 78.1 ± 4.8 years). Disability, defined as difficulty in any of six activities of daily living, was assessed every 6-12 months for 14 years. Frailty was defined according to five standard criteria at the 1996-1997 visit. Cox proportional hazard models estimated the relationship between CML and incident disability (N = 2,643). Logistic regression models estimated the relationship between CML and prevalent frailty.<br />Results: Adjusting for multiple potential confounders, higher CML was associated with incident disability (hazard ratio per standard deviation [225 ng/mL] increase: 1.05, 95% CI 1.01-1.11). In men, odds of frailty increased with higher CML values (odds ratio = 1.30 per standard deviation, 95% CI 1.14-1.48), but the relationship was attenuated by adjustment for cognitive status, kidney function, and arthritis. CML was not associated with frailty in women.<br />Conclusions: Higher serum CML levels in late life are associated with incident disability and prevalent frailty. Further work is needed to understand CML's value as a risk stratifier, biomarker, or target for interventions that promote healthy aging.<br /> (© The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
Cardiac Rehabilitation
Cardiovascular Diseases epidemiology
Female
Follow-Up Studies
Humans
Incidence
Lysine blood
Male
Prevalence
Prognosis
Retrospective Studies
United States epidemiology
Activities of Daily Living
Aging blood
Cardiovascular Diseases blood
Disabled Persons
Frail Elderly
Health Status
Lysine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1758-535X
- Volume :
- 69
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24127427
- Full Text :
- https://doi.org/10.1093/gerona/glt155