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A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.
- Source :
-
Clinical biochemistry [Clin Biochem] 2014 Jan; Vol. 47 (1-2), pp. 126-8. Date of Electronic Publication: 2013 Oct 11. - Publication Year :
- 2014
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Abstract
- Background: It is unknown whether low serum pepsinogen I and pepsinogen I/II ratio (PGI-PGI/II), a marker for chronic atrophic gastritis, is associated with low or high body weight.<br />Methods: We investigated the association between low PGI-PGI/II and both ends of the spectrum of body mass index (BMI) in 819 apparently healthy Japanese men aged 20-75 years who received a medical check-up in 2008.<br />Results: In univariate analysis, serum pepsinogen I, but not pepsinogen II or pepsinogen I/II, was significantly reduced across the increasing BMI categories. Multivariate regression analysis showed that, compared with BMI 21.0-22.9 kg/m(2), BMI of 20.9 kg/m(2) and less or 25.0 kg/m(2) and above was significantly associated with low PGI-PGI/II (pepsinogen I<50 ng/ml combined with PG I/II<3.0), even after adjustment for relevant confounders. These associations showed a J-shaped curve against BMI.<br />Conclusion: Low PGI-PGI/II may be independently associated with both low body weight and obesity in Japanese men.<br /> (© 2013.)
Details
- Language :
- English
- ISSN :
- 1873-2933
- Volume :
- 47
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24125879
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2013.10.003