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[Role of small-dose recombinant human coagulation factor VIIa for coagulopathy in patients with isolated traumatic brain injury].
- Source :
-
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2013 Jun 18; Vol. 93 (23), pp. 1780-3. - Publication Year :
- 2013
-
Abstract
- Objective: To explore the role of small-dose recombinant human coagulation factor VIIa (rFVIIa) for coagulopathy in patients with isolated traumatic brain injury.<br />Methods: A total of 86 isolated traumatic brain patients with coagulopathy were treated at our neurosurgery intensive care unit (NICU) from January 2010 to December 2012. Their trauma registry data included mortality, pre-and post-rFVIIa coagulation parameters. Two-tailed paired t-test was used to determine significant changes in coagulation parameters and other major clinical parameters.<br />Results: Twenty-seven patients made up the low-dose rFVIIa (20 µg/kg) group. And the control group had 59 well-matched subjects. At admission, age, blood pressure, Glasgow coma scale score, hemoglobin, platelets and international normalize ratio were similar in both groups. After treatment, the INR of patients on rFVIIa was lower than that of the conventional treatment group (1.1 ± 0.2 vs 1.2 ± 0.2, P < 0.01) and it declined more in the rFVIIa group (0.3 ± 0.2 vs 0.1 ± 0.4, P = 0.05). No significant difference existed in mortality or length of stay between two groups.There was no occurrence of subsequent thromboembolic events.<br />Conclusion: The application of small-dose rFVIIa can effectively reduce the value of INR and improve the coagulation status of patients. During the course of treatment, no major adverse events occur.
- Subjects :
- Adult
Blood Coagulation Disorders etiology
Brain Injuries complications
Factor VIIa therapeutic use
Female
Humans
Male
Middle Aged
Recombinant Proteins administration & dosage
Recombinant Proteins therapeutic use
Blood Coagulation Disorders drug therapy
Brain Injuries drug therapy
Factor VIIa administration & dosage
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0376-2491
- Volume :
- 93
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 24124708