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Copper-catalyzed borylation of α-alkoxy allenes with bis(pinacolato)diboron: efficient synthesis of 2-boryl 1,3-butadienes.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Nov 18; Vol. 52 (47), pp. 12400-3. Date of Electronic Publication: 2013 Oct 02. - Publication Year :
- 2013
-
Abstract
- Something solid to build on: 2-Boryl 1,3-butadienes with various substitution patterns were formed in good to high yields in a copper-catalyzed borylation of α-alkoxy allenes with bis(pinacolato)diboron (see scheme; Bn=benzyl, pin=pinacolate, L is an N-heterocyclic carbene ligand). The products were found to be useful intermediates for the synthesis of cyclic vinyl boranes, α,β-unsaturated ketones, and functionalized multisubstituted dienes.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 52
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 24123693
- Full Text :
- https://doi.org/10.1002/anie.201306843