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The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse.
- Source :
-
Immunological reviews [Immunol Rev] 2013 Nov; Vol. 256 (1), pp. 203-21. - Publication Year :
- 2013
-
Abstract
- Natural killer (NK) cells discriminate between healthy and unhealthy target cells through a balance of activating and inhibitory signals at direct intercellular contacts called immune synapses. Rearrangements in the cellular cytoskeleton have long been known to be critical in assembly of immune synapses. Here, through bringing together the vast literature on this subject, the number of different ways in which the cytoskeleton is important becomes evident. The dynamics of filamentous actin are critical in (i) creating the nanometer-scale organization of NK cell receptors, (ii) establishing cellular polarity, (iii) coordinating immune receptor and integrin-mediated signaling, and (iv) directing secretion of lytic granules and cytokines. The microtubule network also is important in the delivery of lytic granules and vesicles containing cytokines to the immune synapse. Together, these data establish that the cytoskeleton acts as a central regulator of this complex and dynamic process - and an enormous amount of NK cell biology is controlled through the cytoskeleton.<br /> (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Actins metabolism
Animals
Cell Adhesion
Cell Membrane metabolism
Cell Movement
Humans
Integrins metabolism
Lymphocyte Activation
Microtubule-Organizing Center metabolism
Protein Binding
Receptors, Cell Surface metabolism
Signal Transduction
Cytoskeleton physiology
Immunological Synapses physiology
Killer Cells, Natural physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-065X
- Volume :
- 256
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunological reviews
- Publication Type :
- Academic Journal
- Accession number :
- 24117823
- Full Text :
- https://doi.org/10.1111/imr.12107