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End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation.

Authors :
Mascia S
Heider PL
Zhang H
Lakerveld R
Benyahia B
Barton PI
Braatz RD
Cooney CL
Evans JM
Jamison TF
Jensen KF
Myerson AS
Trout BL
Source :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Nov 18; Vol. 52 (47), pp. 12359-63. Date of Electronic Publication: 2013 Oct 02.
Publication Year :
2013

Abstract

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1521-3773
Volume :
52
Issue :
47
Database :
MEDLINE
Journal :
Angewandte Chemie (International ed. in English)
Publication Type :
Academic Journal
Accession number :
24115355
Full Text :
https://doi.org/10.1002/anie.201305429