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Nanocarriers for delivery of platinum anticancer drugs.
- Source :
-
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2013 Nov; Vol. 65 (13-14), pp. 1667-85. Date of Electronic Publication: 2013 Oct 08. - Publication Year :
- 2013
-
Abstract
- Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.<br /> (© 2013.)
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacokinetics
Antineoplastic Agents therapeutic use
Clinical Trials as Topic
Dose-Response Relationship, Drug
Drug Discovery
Humans
Molecular Structure
Organoplatinum Compounds chemistry
Organoplatinum Compounds pharmacokinetics
Organoplatinum Compounds therapeutic use
Platinum Compounds chemistry
Platinum Compounds pharmacokinetics
Platinum Compounds therapeutic use
Antineoplastic Agents administration & dosage
Drug Carriers chemistry
Drug Resistance, Neoplasm
Nanoparticles chemistry
Organoplatinum Compounds administration & dosage
Platinum Compounds administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8294
- Volume :
- 65
- Issue :
- 13-14
- Database :
- MEDLINE
- Journal :
- Advanced drug delivery reviews
- Publication Type :
- Academic Journal
- Accession number :
- 24113520
- Full Text :
- https://doi.org/10.1016/j.addr.2013.09.014