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Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study.

Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study.

Authors :
Visser MJ
Verberk MM
Campbell LE
McLean WH
Calkoen F
Bakker JG
van Dijk FJ
Bos JD
Kezic S
Source :
Contact dermatitis [Contact Dermatitis] 2014 Mar; Vol. 70 (3), pp. 139-50. Date of Electronic Publication: 2013 Sep 19.
Publication Year :
2014

Abstract

Background/objectives: Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss-of-function mutations in the filaggrin gene (FLG), atopic dermatitis and wet work exposure on the development of hand eczema in apprentice nurses.<br />Methods: Dutch apprentice nurses were genotyped for the four most common FLG mutations; atopic dermatitis and hand eczema history were assessed by questionnaire. Exposure and hand eczema during traineeships were assessed with diary cards.<br />Results: The prevalence of hand eczema during traineeships was higher among subjects with a history of hand eczema reported at inclusion. Hand washing during traineeships and at home increased the risk of hand eczema. After adjustment for the effects of exposure and FLG mutations, an odds ratio of 2.5 (90% confidence interval 1.7-3.7) was found for a history of atopic dermatitis. In this study, an increased risk of hand eczema conferred by FLG mutations could not be shown, but subjects with concomitant FLG mutations and atopic dermatitis showed the highest risk of hand eczema during traineeships.<br />Conclusion: A history of atopic dermatitis, a history of hand eczema and wet work exposure were the most important factors increasing the risk of hand eczema during traineeships.<br /> (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1600-0536
Volume :
70
Issue :
3
Database :
MEDLINE
Journal :
Contact dermatitis
Publication Type :
Academic Journal
Accession number :
24102300
Full Text :
https://doi.org/10.1111/cod.12139