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Heat-tolerant versus heat-sensitive Bos taurus cattle: influence of air temperature and breed on the metabolic response to a provocative immune challenge.
- Source :
-
Domestic animal endocrinology [Domest Anim Endocrinol] 2013 Nov; Vol. 45 (4), pp. 180-6. Date of Electronic Publication: 2013 Sep 20. - Publication Year :
- 2013
-
Abstract
- The response of the immune and stress systems have been assessed in response to a lipopolysaccharide (LPS) challenge, yet the role of metabolism in mediating energy requirements during the acute phase response has not been sufficiently studied. This study tested heat-tolerant (Romosinuano [RO]) and heat-sensitive (Angus [ANG]) Bos taurus breeds at different ambient temperatures (Ta) to determine differential metabolic responses to LPS challenge. Twenty-one heifers (ANG: n = 11, 306 ± 26 kg BW; RO: n = 10, 313 ± 32 kg BW) were housed in stanchions in 4 temperature-controlled chambers. Initially, Ta in all 4 chambers was cycling at thermoneutrality (TN; 18.5°C-23.5°C) for a 1-wk adjustment period, followed by an increase in 2 chambers to cycling heat stress (HS; 24°C-38°C) for 2 wk. Five ANG and 5 RO heifers were housed at TN, whereas 6 ANG and 5 RO heifers were housed at HS. On day 19, heifers were fitted with jugular catheters. On day 20, heifers were challenged with LPS (0.5 μg/kg BW; 0 h), and blood samples were collected from -2 to 8 h and at 24 h relative to LPS challenge. Serum was analyzed for glucose, insulin, and NEFA concentrations. In addition, feed intake was measured 3 d before and on the day of the challenge. Feed intake decreased over time (P < 0.001) and was decreased in heifers housed at HS compared with heifers housed at TN (P = 0.013). Glucose concentrations before LPS challenge were greater in RO (P = 0.01) than in ANG heifers and greater in TN-housed heifers (P = 0.02) than in HS heifers. Glucose after LPS challenge initially increased before decreasing below baseline concentrations (P < 0.01) in all heifers. In addition, there was a breed by Ta interaction (P < 0.004), such that HS decreased glucose concentrations in ANG heifers compared with ANG heifers housed at TN (P < 0.001), whereas HS did not affect glucose concentrations after LPS challenge in RO heifers (P = 0.941). Nonesterified fatty acid concentrations before LPS challenge were not affected by breed (P = 0.37) or Ta (P = 0.60). Although NEFA concentration after LPS challenge was unaffected by Ta (P = 0.78), there tended to be a breed by Ta interaction (P = 0.07) such that, when housed at HS, RO heifers had greater serum NEFA concentrations after LPS challenge than ANG heifers (P = 0.009). Insulin concentration before LPS challenge was greater in RO heifers than in ANG heifers (P < 0.01). Insulin after LPS challenge increased (P < 0.01), with RO heifers producing a greater insulin response than ANG heifers (P < 0.01). These data suggest that HS decreases the metabolic response of heat-sensitive ANG heifers in response to LPS challenge, thus providing physiological evidence that may explain differences observed in the acute phase response between heat-sensitive ANG and heat-tolerant RO cattle breeds.<br /> (Published by Elsevier Inc.)
- Subjects :
- Acute-Phase Reaction genetics
Acute-Phase Reaction veterinary
Animals
Blood Glucose analysis
Cattle genetics
Cattle Diseases genetics
Fatty Acids, Nonesterified blood
Female
Insulin blood
Lipopolysaccharides immunology
Species Specificity
Stress, Physiological genetics
Stress, Physiological immunology
Temperature
Breeding
Cattle physiology
Hot Temperature adverse effects
Immunity physiology
Stress, Physiological physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0054
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Domestic animal endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 24099737
- Full Text :
- https://doi.org/10.1016/j.domaniend.2013.08.005