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Liver steatosis (LS) evaluated through chemical-shift magnetic resonance imaging liver enzymes in morbid obesity; effect of weight loss obtained with intragastric balloon gastric banding.
- Source :
-
Acta diabetologica [Acta Diabetol] 2014; Vol. 51 (3), pp. 361-8. Date of Electronic Publication: 2013 Oct 02. - Publication Year :
- 2014
-
Abstract
- The aim of this study was to evaluate in morbid obesity clinical and metabolic effects related to weight loss on liver steatosis (LS), measured through chemical-shift magnetic resonance imaging (MRI) and liver enzymes. Forty obese subjects (8 M/32 W; BMI 42.8 ± 7.12 kg/m(2), mean ± SD) were evaluated for LS through ultrasound (US-LS), chemical-shift MRI (MRI-LS), liver enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), alkaline phosphatase (ALP)], anthropometric parameters [weight, BMI, waist circumference (WC)], lipids, insulin, insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), oral glucose tolerance test, and body composition [fat mass (FM) and fat-free mass (FFM) at bio-impedance analysis (BIA)]. Anthropometric measures, MRI-LS, BIA, and biochemical parameters were reevaluated 6 months later in 18 subjects undergoing restrictive bariatric approach, i.e., intragastric balloon (BIB, n = 13) or gastric banding (LAGB, n = 5), and in 13 subjects receiving hypocaloric diet. At baseline, US-LS correlates only with MRI-LS, and the latter correlates with ALT, AST, and GGT. After 6 months, subjects undergoing BIB or LAGB had significant changes of BMI, weight, WC, ALT, AST, GGT, ALP, HbA1c, insulin, HOMA-IR, FM, FFM, and MRI-LS. Diet-treated obese subjects had no significant change of any parameter under study; change of BMI, fat mass, and fat-free mass was significantly greater in LAGB/BIB subjects than in diet-treated subjects. Change of MRI-LS showed a significant correlation with changes in weight, BMI, WC, GGT, ALP, and basal MRI-LS. Significant weight loss after BIB or LAGB is associated with decrease in chemical-shift MRI-LS and with reduction in liver enzymes; chemical-shift MRI and liver enzymes allow monitoring of LS in follow-up studies.
- Subjects :
- Adolescent
Adult
Aged
Alanine Transaminase metabolism
Aspartate Aminotransferases metabolism
Bariatric Surgery instrumentation
Fatty Liver diagnostic imaging
Fatty Liver enzymology
Fatty Liver etiology
Female
Gastric Balloon
Humans
Insulin metabolism
Magnetic Resonance Imaging
Male
Middle Aged
Obesity, Morbid complications
Obesity, Morbid diagnostic imaging
Obesity, Morbid physiopathology
Radiography
Treatment Outcome
Young Adult
gamma-Glutamyltransferase metabolism
Fatty Liver diagnosis
Liver blood supply
Liver enzymology
Obesity, Morbid surgery
Weight Loss
Subjects
Details
- Language :
- English
- ISSN :
- 1432-5233
- Volume :
- 51
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta diabetologica
- Publication Type :
- Academic Journal
- Accession number :
- 24085682
- Full Text :
- https://doi.org/10.1007/s00592-013-0516-4