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In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A-C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2014 Feb; Vol. 67 (2), pp. 163-6. Date of Electronic Publication: 2013 Oct 02. - Publication Year :
- 2014
-
Abstract
- During the search for new antitrypanosomal drug leads, three new antitrypanosomal compounds, cardinalisamides A-C (1-3), were isolated from cultures of the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. Their structures were elucidated using MS analyses and extensive 2D-heteronuclear NMR. The absolute configurations of 1-3 were addressed by chemical degradation and Marfey's analysis. 1-3 showed in vitro antitrypanosomal activity against Trypanosoma brucei brucei with IC50 values of 8.56, 8.65 and 8.63 μg ml(-1), respectively.
- Subjects :
- Animals
Depsipeptides chemistry
Depsipeptides isolation & purification
Drug Discovery
Humans
Trypanocidal Agents chemistry
Trypanocidal Agents isolation & purification
Trypanosoma brucei brucei drug effects
Trypanosomiasis, African drug therapy
Cordyceps chemistry
Depsipeptides pharmacology
Lepidoptera microbiology
Trypanocidal Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 24084682
- Full Text :
- https://doi.org/10.1038/ja.2013.93