IFITMs restrict the replication of multiple pathogenic viruses.

Authors :: Perreira JM
Chin CR
Feeley EM
Brass AL
Source :: Journal of molecular biology [J Mol Biol] 2013 Dec 13; Vol. 425 (24), pp. 4937-55. Date of Electronic Publication: 2013 Sep 25.
Publication Year :: 2013
Abstract: The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.<br /> (© 2013.)