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Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis.
- Source :
-
Atherosclerosis [Atherosclerosis] 2013 Oct; Vol. 230 (2), pp. 242-8. Date of Electronic Publication: 2013 Jul 20. - Publication Year :
- 2013
-
Abstract
- Background: Inverse correlations of high serum bilirubin with metabolic and cardiovascular disease have been suggested. However, anti-atherogenic effects of bilirubin have not been well-established in terms of the presence of plaques and stenosis identified in coronary computed tomography (CT).<br />Methods: A cross-sectional study was conducted on 2862 men who were free of cardiovascular disease and underwent coronary CT as part of a routine medical screening examination. Coronary stenotic lesions were considered to be incidences of coronary atherosclerosis, and stenosis was classified as stenosis <50% or ≥50%, according to degree of stenosis.<br />Results: The prevalences of coronary atherosclerosis and stenosis ≥50% in subjects with elevated bilirubin levels (>1.2 mg/dL) were lower than those in subjects with normal bilirubin levels (≤1.2 mg/dL) (19.9% vs. 27.9%, p < 0.001, 8.5% vs. 10.3%, p = 0.044). Bilirubin was inversely associated with total plaques (odds ratio [OR] 0.59, 95% confidence interval [CI] 0.48-0.73 in the 4th quartile vs. 1st quartile) and calcified plaques (OR 0.60, 95% CI 0.49-0.75) in univariate analysis. After adjusting for traditional risk factors, it was found that coronary atherosclerosis (OR 0.73, 95% CI 0.56-0.94 in the 4th quartile vs. 1st quartile) and calcified plaque (OR 0.66, 95% CI 0.53-0.84) were inversely associated with the bilirubin grade in a dose-dependent manner.<br />Conclusions: The serum bilirubin level was inversely associated with coronary atherosclerosis and calcified plaques in a dose-dependent manner. These results suggested that serum bilirubin could be used as a protective biomarker of coronary artery disease.<br /> (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Aged
Anthropometry
Atherosclerosis diagnostic imaging
Atherosclerosis pathology
Blood Pressure
Constriction, Pathologic diagnostic imaging
Cross-Sectional Studies
Humans
Male
Middle Aged
Multidetector Computed Tomography
Multivariate Analysis
Odds Ratio
Plaque, Atherosclerotic pathology
Risk Factors
Surveys and Questionnaires
Tomography, X-Ray Computed
Atherosclerosis blood
Bilirubin blood
Constriction, Pathologic pathology
Coronary Vessels pathology
Plaque, Atherosclerotic blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 230
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 24075751
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2013.06.021