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Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.
- Source :
-
Trends in cell biology [Trends Cell Biol] 2013 Dec; Vol. 23 (12), pp. 593-602. Date of Electronic Publication: 2013 Sep 25. - Publication Year :
- 2013
-
Abstract
- Multifocal and recurrent epithelial tumors, originating from either dormant or de novo cancer cells, are major causes of morbidity and mortality. The age-dependent increase of cancer incidence has long been assumed to result from the sequential accumulation of cancer-driving or -facilitating mutations with induction of cellular senescence as a protective mechanism. However, recent evidence suggests that the initiation and development of epithelial cancer results from a close interplay with its altered tissue microenvironment, with chronic inflammation, stromal senescence, autophagy, and the activation of cancer-associated fibroblasts (CAFs) playing possible primary roles. We will discuss recent progress in these areas, and highlight how this understanding may be used for devising novel preventive and therapeutic approaches to the epithelial cancer problem.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3088
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Trends in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 24074947
- Full Text :
- https://doi.org/10.1016/j.tcb.2013.08.006