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Dancing with chemical formulae of antivirals: A panoramic view (Part 2).
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 2013 Nov 15; Vol. 86 (10), pp. 1397-410. Date of Electronic Publication: 2013 Sep 23. - Publication Year :
- 2013
-
Abstract
- In this second part of "Dancing with antivirals as chemical formulae" I will focus on a number of chemical compounds that in the last few years have elicited more than common attraction from a commercial viewpoint: (i) favipiravir (T-705), as it is active against influenza, but also several other RNA viruses; (ii) neuraminidase inhibitors such as zanamivir and oseltamivir; (iii) peramivir and laninamivir octanoate, which might be effective against influenza virus following a single (intravenous or inhalation) administration; (iv) sofosbuvir, the (anticipated) cornerstone for the interferon-free therapy of HCV infections; (v) combinations of DAAs (direct antiviral agents) to achieve, in no time, a sustained virus response (SVR) against HCV infection; (vi) HIV protease inhibitors, the latest and most promising being darunavir; (vii) the integrase inhibitors (INIs) (raltegravir, elvitegravir, dolutegravir), representing a new dimension in the anti-HIV armamentarium; (viii), a new class of helicase primase inhibitors (HPIs) that may exceed acyclovir and the other anti-herpes compounds in both potency and safety; (ix) CMX-001, as the latest of Dr. Antonín Holý's legacy for its activity against poxviruses and CMV infections, and (x) noroviruses for which the ideal antiviral compounds are still awaited for.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-2968
- Volume :
- 86
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 24070654
- Full Text :
- https://doi.org/10.1016/j.bcp.2013.09.010