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Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida.
- Source :
-
Fitoterapia [Fitoterapia] 2013 Dec; Vol. 91, pp. 217-223. Date of Electronic Publication: 2013 Sep 20. - Publication Year :
- 2013
-
Abstract
- Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human cancer cell lines were assayed, and most interestingly, compound 10 revealed preferred cytotoxicity on the HT-1080 cell line and displayed much stronger inhibitory activity (IC50=8.86 μM) compared with positive control 5-fluorouracil (IC50=35.62 μM). Meanwhile, antioxidant activities of all the isolates were evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, and the results showed that most of the isolates exhibited potent antioxidant activity.<br /> (© 2013.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Antioxidants chemistry
Antioxidants isolation & purification
Antioxidants pharmacology
Benzofurans chemistry
Benzofurans isolation & purification
Benzofurans pharmacology
Benzothiazoles metabolism
Biphenyl Compounds metabolism
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Lignans chemistry
Lignans isolation & purification
Lignans pharmacology
Molecular Structure
Picrates metabolism
Plant Extracts chemistry
Plant Extracts pharmacology
Plant Extracts therapeutic use
Seeds chemistry
Sulfonic Acids metabolism
Antineoplastic Agents, Phytogenic therapeutic use
Antioxidants therapeutic use
Benzofurans therapeutic use
Crataegus chemistry
Lignans therapeutic use
Neoplasms drug therapy
Phytotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 91
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 24060910
- Full Text :
- https://doi.org/10.1016/j.fitote.2013.09.011