Back to Search
Start Over
The effects of venlafaxine and cognitive behavioral therapy alone and combined in the treatment of co-morbid alcohol use-anxiety disorders.
- Source :
-
Behaviour research and therapy [Behav Res Ther] 2013 Nov; Vol. 51 (11), pp. 729-35. Date of Electronic Publication: 2013 Aug 30. - Publication Year :
- 2013
-
Abstract
- The effects of the antidepressant venlafaxine (VEN-225 mg daily) and transdiagnostic cognitive behavioral treatment (CBT) alone and in combination on alcohol intake in subjects with co-morbid alcohol use disorders (AUDs) and anxiety disorders were compared. Drinking outcomes and anxiety were assessed for 81 subjects treated for 11 weeks with one of 4 conditions: 1) VEN-CBT, 2) VEN-Progressive Muscle Relaxation therapy (PMR), 3) Placebo (PLC)-CBT and 4) a comparison group of PLC-PMR. For subjects who reported taking at least one dose of study medication, the Time×Group interaction was significant for percent days of heavy drinking and drinks consumed per day. For the measure of percent days heavy drinking, the paired comparison of PLC-CBT versus PLC-PMR group indicated that the PLC-CBT group had greater drinking reductions, whereas other groups were not superior to the comparison group. In Week 11, the proportion of subjects in the PLC-CBT group that had a 50% reduction from baseline in percent days heavy drinking was significantly greater than those in the comparison group. Of the 3 "active treatment" groups only the PLC-CBT group had significantly decreased heavy drinking when contrasted to the comparison group. This finding suggests that the transdiagnostic CBT approach of Barlow and colleagues may have value in the management of heavy drinking in individuals with co-morbid alcoholism and anxiety.<br /> (Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Adult
Alcohol Drinking drug therapy
Alcohol Drinking therapy
Alcohol-Related Disorders drug therapy
Antidepressive Agents, Second-Generation therapeutic use
Anxiety Disorders drug therapy
Cyclohexanols adverse effects
Double-Blind Method
Female
Humans
Male
Medication Adherence
Relaxation Therapy
Venlafaxine Hydrochloride
Alcohol-Related Disorders complications
Alcohol-Related Disorders therapy
Anxiety Disorders complications
Anxiety Disorders therapy
Cognitive Behavioral Therapy methods
Combined Modality Therapy methods
Cyclohexanols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1873-622X
- Volume :
- 51
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Behaviour research and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 24055681
- Full Text :
- https://doi.org/10.1016/j.brat.2013.08.003