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[Vitamin D and kidney diseases].
- Source :
-
Presse medicale (Paris, France : 1983) [Presse Med] 2013 Oct; Vol. 42 (10), pp. 1391-7. Date of Electronic Publication: 2013 Sep 20. - Publication Year :
- 2013
-
Abstract
- Calcitriol and analogs inhibit renin-angiotensin system, which has a pivotal role in glomerular and tubulo-interstitial damages and proteinuria, and inhibit NF-κB activation which is known to play an important role in renal diseases by promoting inflammation and fibrogenesis. Vitamin D presents interesting pleiotropic effects for the CKD patient (reduction of mortality, antiproteinuric effect and anti-inflammatory properties). "Native" vitamin D (cholecalciferol or ergocalciferol) administration in these patients also decrease parathyroid hormone levels. Native vitamin D administration in CKD patients is safe and does not lead to increased risk of vascular calcification, despite the known hypercalcemic and hyperphosphoremic properties of the molecule in its active form. Native vitamin D administration is not associated with an increased risk of renal stones, at pharmacological doses and without important concomitant administration of calcium salts. In the field of renal transplantation, experimental studies show that vitamin D analogs have a protective role against acute rejection but clinical studies remain mainly observational.<br /> (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Cytoprotection drug effects
Cytoprotection physiology
Humans
Kidney drug effects
Kidney metabolism
Kidney physiology
Kidney Diseases complications
Kidney Diseases etiology
Kidney Diseases metabolism
Kidney Transplantation
Lithiasis drug therapy
Lithiasis epidemiology
Lithiasis metabolism
Renal Dialysis
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic drug therapy
Renal Insufficiency, Chronic metabolism
Renin-Angiotensin System drug effects
Renin-Angiotensin System physiology
Vitamin D analogs & derivatives
Vitamin D metabolism
Vitamin D Deficiency complications
Vitamin D Deficiency drug therapy
Vitamin D Deficiency epidemiology
Vitamin D Deficiency metabolism
Kidney Diseases drug therapy
Vitamin D physiology
Vitamin D therapeutic use
Subjects
Details
- Language :
- French
- ISSN :
- 2213-0276
- Volume :
- 42
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Presse medicale (Paris, France : 1983)
- Publication Type :
- Academic Journal
- Accession number :
- 24055557
- Full Text :
- https://doi.org/10.1016/j.lpm.2013.07.011