Association of blood type and patient characteristics with ovarian reserve.

Objective: To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age.
Design: Cross-sectional study.
Setting: Academic medical center, Division of Reproductive Endocrinology and Infertility.
Patient(s): Women undergoing in vitro fertilization (IVF) from 2006-2011 (n = 305).
Intervention(s): None.
Main Outcome Measure(s): Presence of DOR in relation to a patient's blood type.
Result(s): Other investigators have reported an increased risk for DOR in patients with blood type O and a protective effect on ovarian reserve for blood type A. We observed no association between a woman's blood type and DOR. We found an increased risk for DOR in patients aged 35 and older. Obesity (BMI ≥ 30 vs. BMI <25) was associated with lower odds of DOR.
Conclusion(s): In comparison with blood type A, blood type O is not associated with an increase in DOR. We found no clinical implications for using blood type as a risk factor for DOR.
(Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)