A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes.

Authors :: Araújo JR
Ramalho C
Correia-Branco A
Faria A
Ferraz T
Keating E
Martel F
Source :: Placenta [Placenta] 2013 Nov; Vol. 34 (11), pp. 1095-8. Date of Electronic Publication: 2013 Sep 11.
Publication Year :: 2013
Abstract: We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)

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