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Regulation of human ovarian insulin receptors in vivo.
- Source :
-
Metabolism: clinical and experimental [Metabolism] 1990 Feb; Vol. 39 (2), pp. 161-6. - Publication Year :
- 1990
-
Abstract
- Insulin participates in regulating ovarian function in normal and in pathological states. This effect of insulin may be mediated by ovarian insulin receptors. We have previously characterized human ovarian insulin receptors and began to examine their regulation in vitro. The present study examines regulation of human ovarian insulin receptors in vivo. Stromal ovarian tissue was obtained from 21 women during an indicated surgical procedure. Ten women were premenopausal and 11 were postmenopausal. Specific 125I-insulin binding to stromal ovarian fragments ranged from 2.5% to 7.3%/mg protein. 125I-insulin binding to stromal fragments correlated positively with 125I-insulin binding to circulating leucocytes (r = .57; P less than .01). When postmenopausal and premenopausal women were analyzed separately, this relationship persisted in postmenopausal women (r = .70; P less than .05), but not premenopausal women. 125I-insulin binding to stromal ovarian fragments correlated negatively with age (r = -.63; P = .005). 125I-insulin binding to stromal ovarian fragments tended to correlate negatively with plasma insulin levels in postmenopausal women (r = -.67; P = .06), but not in premenopausal women. Plasma insulin levels correlated negatively with serum SHBG (r = -.62; P = .003). The percent free testosterone levels correlated positively with plasma insulin levels in premenopausal women (r = .95; P = .0001), but not in postmenopausal women.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Age Factors
Aged
Binding Sites
Female
Humans
Insulin metabolism
Leukocytes analysis
Leukocytes metabolism
Menopause
Middle Aged
Ovary drug effects
Ovary metabolism
Radioimmunoassay
Receptor, Insulin drug effects
Sex Factors
Testosterone metabolism
Insulin physiology
Ovary physiology
Receptor, Insulin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0026-0495
- Volume :
- 39
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Metabolism: clinical and experimental
- Publication Type :
- Academic Journal
- Accession number :
- 2405234
- Full Text :
- https://doi.org/10.1016/0026-0495(90)90070-s