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Autologous bone marrow transplantation in acute myeloid leukemia in first remission: results of a Dutch prospective study.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 1990 Feb; Vol. 8 (2), pp. 287-94. - Publication Year :
- 1990
-
Abstract
- Recent investigations have suggested a role for marrow ablative chemotherapy and radiotherapy given with autologous bone marrow transplantation (auto-BMT) in the treatment of acute myeloid leukemia (AML), but prospective studies have not been reported. We assessed the comparative values of auto-BMT and allogeneic marrow transplantation (allo-BMT) in 117 15- to 60-year-old consecutive patients (median, 43 years) with AML following remission-induction therapy. In 32 cases of the 90 (77%) complete responders, auto-BMT (nonpurged) was undertaken at a median of 3.8 months and in 23 eligible cases human leukocyte antigen (HLA)-matched allo-BMT occurred at 3.0 months after attainment of remission. Thus, nearly 60% of complete responders had access to transplantation, the others being withdrawn because of relapse, refusal, or other causes. Median time of regeneration to neutrophils 0.5 x 10(9)/L and platelets 20 x 10(9)/L were 39 and 63 days following auto-BMT versus 21 and 19 days after allo-BMT, respectively. AML relapse was the predominant cause of failure after auto-BMT (17 of 32) and procedure-related death was seen in three of 32 patients. The actuarial rates of relapse at 3 years are 60% (auto-BMT) and 34% (allo-BMT) (log-rank, P = .03). Patients treated with auto-BMT and allo-BMT have an overall survival of 37% and 66% at 3 years posttransplant, respectively (P = .05). Relapse-free 3-year survival rates are 35% and 51%, respectively (P = .12). Survival of the nongrafted complete responders is less than 10%. This study shows that allo-BMT in adult patients with AML in first complete remission (CR) results in more rapid hematopoietic reconstitution, is followed by fewer recurrences, and provides better survival than auto-BMT.
- Subjects :
- Actuarial Analysis
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bone Marrow pathology
Follow-Up Studies
Humans
Leukemia, Myeloid, Acute drug therapy
Leukemia, Myeloid, Acute mortality
Leukemia, Myeloid, Acute radiotherapy
Middle Aged
Netherlands
Prospective Studies
Remission Induction
Survival Rate
Whole-Body Irradiation
Bone Marrow Transplantation methods
Leukemia, Myeloid, Acute surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0732-183X
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 2405106
- Full Text :
- https://doi.org/10.1200/JCO.1990.8.2.287