Back to Search
Start Over
Epidemiologic study of residential proximity to transmission lines and childhood cancer in California: description of design, epidemiologic methods and study population.
- Source :
-
Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2015 Jan; Vol. 25 (1), pp. 45-52. Date of Electronic Publication: 2013 Sep 18. - Publication Year :
- 2015
-
Abstract
- We conducted a large epidemiologic case-control study in California to examine the association between childhood cancer risk and distance from the home address at birth to the nearest high-voltage overhead transmission line as a replication of the study of Draper et al. in the United Kingdom. We present a detailed description of the study design, methods of case ascertainment, control selection, exposure assessment and data analysis plan. A total of 5788 childhood leukemia cases and 3308 childhood central nervous system cancer cases (included for comparison) and matched controls were available for analysis. Birth and diagnosis addresses of cases and birth addresses of controls were geocoded. Distance from the home to nearby overhead transmission lines was ascertained on the basis of the electric power companies' geographic information system (GIS) databases, additional Google Earth aerial evaluation and site visits to selected residences. We evaluated distances to power lines up to 2000 m and included consideration of lower voltages (60-69 kV). Distance measures based on GIS and Google Earth evaluation showed close agreement (Pearson correlation >0.99). Our three-tiered approach to exposure assessment allowed us to achieve high specificity, which is crucial for studies of rare diseases with low exposure prevalence.
- Subjects :
- Adolescent
California epidemiology
Central Nervous System Neoplasms epidemiology
Central Nervous System Neoplasms etiology
Child
Child, Preschool
Electric Wiring statistics & numerical data
Environmental Exposure statistics & numerical data
Epidemiologic Methods
Female
Humans
Infant
Leukemia epidemiology
Leukemia etiology
Male
Neoplasms etiology
Registries
SEER Program
Electric Wiring adverse effects
Electromagnetic Fields adverse effects
Environmental Exposure adverse effects
Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-064X
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of exposure science & environmental epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 24045429
- Full Text :
- https://doi.org/10.1038/jes.2013.48