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Ten-day Quadruple therapy comprising proton-pump inhibitor, bismuth, tetracycline, and levofloxacin achieves a high eradication rate for Helicobacter pylori infection after failure of sequential therapy.
- Source :
-
Helicobacter [Helicobacter] 2014 Feb; Vol. 19 (1), pp. 74-9. Date of Electronic Publication: 2013 Sep 06. - Publication Year :
- 2014
-
Abstract
- Background: Sequential therapy has been recommended in the Maastricht IV/Florence Consensus Report as the first-line treatment for Helicobacter pylori eradication in regions with high clarithromycin resistance. However, it fails in 5-24% of infected subjects, and the recommended levofloxacin-containing triple rescue therapy only achieves a 77% eradication rate after failure of sequential therapy.<br />Aim: To investigate the efficacy of a novel quadruple therapy comprising proton-pump inhibitor, bismuth, tetracycline, and levofloxacin for rescue treatment of sequential therapy.<br />Methods: This was a multicenter study in which H. pylori-infected patients who had failed sequential therapy received a 10-day quadruple therapy (esomeprazole (40 mg b.d), tripotassium dicitrato bismuthate (120 mg q.d.s.), tetracycline (500 mg q.d.s.), and levofloxacin (500 mg o.d.) for 10 days). H. pylori status was examined 6 weeks after the end of treatment.<br />Results: From July 2007 to June 2012, twenty-four subjects received 10-day quadruple therapy. The eradication rates according to intention-to-treat and per-protocol analyses were both 95.8% (23 of 24; 95% confidence interval, 87.8-103.8%). Adverse events were seen in 25.0% (6 of 24) of the patients. Drug compliance was 100.0% (24/24).<br />Conclusions: The 10-day quadruple therapy comprising proton-pump inhibitor, bismuth, tetracycline, and levofloxacin achieves a very high eradication rate for H. pylori infection after failure of sequential therapy. It is well tolerated and has great potential to become a good choice of rescue treatment following non-bismuth-containing quadruple therapy in regions with high clarithromycin resistance.<br /> (© 2013 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Anti-Bacterial Agents adverse effects
Bismuth adverse effects
Drug Therapy, Combination adverse effects
Drug Therapy, Combination methods
Female
Humans
Levofloxacin adverse effects
Male
Middle Aged
Proton Pump Inhibitors adverse effects
Tetracycline adverse effects
Time Factors
Treatment Outcome
Anti-Bacterial Agents administration & dosage
Bismuth administration & dosage
Helicobacter Infections drug therapy
Levofloxacin administration & dosage
Proton Pump Inhibitors administration & dosage
Tetracycline administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1523-5378
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Helicobacter
- Publication Type :
- Academic Journal
- Accession number :
- 24033865
- Full Text :
- https://doi.org/10.1111/hel.12085