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An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2013 Sep 11; Vol. 18 (9), pp. 11144-52. Date of Electronic Publication: 2013 Sep 11. - Publication Year :
- 2013
-
Abstract
- An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 18
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 24029747
- Full Text :
- https://doi.org/10.3390/molecules180911144