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In vitro replication competence of a hepatitis B genotype D/A recombinant virus: dissimilar biological behaviour regarding its parental genotypes.
- Source :
-
The Journal of general virology [J Gen Virol] 2013 Dec; Vol. 94 (Pt 12), pp. 2724-2728. Date of Electronic Publication: 2013 Sep 11. - Publication Year :
- 2013
-
Abstract
- Hepatitis B virus (HBV) DNA recombinants contribute to ~30% of the overall full-length sequences already deposited in GenBank. However, their biological behaviour has not been analysed so far. In this study, the in vitro replication kinetics of the first D/A recombinant from the American continent differed from its parental genotypes, exhibiting higher extracellular levels of HBV DNA and hepatitis B e antigen. Southern blots of intracellular core-associated HBV DNA were in agreement with such results. Because this recombinant was obtained from an Argentinian injecting drug user belonging to a vulnerable community, these results are of singular relevance for regional public health. Further in vivo studies are urgently needed to determine the pathogenicity of these replicative competent clones.
- Subjects :
- Argentina
Base Sequence
DNA, Viral blood
DNA, Viral isolation & purification
Genotype
Hepatitis B e Antigens blood
Hepatitis B virus classification
Hepatitis B virus genetics
Hepatitis B, Chronic virology
Humans
Molecular Sequence Data
Sequence Analysis, DNA
Hepatitis B virus physiology
Recombination, Genetic
Virus Replication
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 94
- Issue :
- Pt 12
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 24026673
- Full Text :
- https://doi.org/10.1099/vir.0.053595-0