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Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury.
- Source :
-
The Journal of toxicological sciences [J Toxicol Sci] 2013; Vol. 38 (5), pp. 703-6. - Publication Year :
- 2013
-
Abstract
- Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the levels of 11 low molecular weight metabolites and significant reductions in the levels of 29 others, including several metabolites produced by amino acid and purine metabolism. Non-significant decreases in metabolites involved in the TCA cycle and in glutathione metabolism were also observed.
- Subjects :
- Amino Acids metabolism
Animals
Cerebellar Diseases metabolism
Citric Acid Cycle
Glutathione metabolism
Male
Metabolomics methods
Mice
Mice, Inbred C57BL
Molecular Weight
Purines metabolism
Cerebellar Diseases chemically induced
Cerebellum metabolism
Methylmercury Compounds metabolism
Methylmercury Compounds toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1880-3989
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of toxicological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24025787
- Full Text :
- https://doi.org/10.2131/jts.38.703