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Seroprevalence of rubella in the cord blood of pregnant women and congenital rubella incidence in Nha Trang, Vietnam.
- Source :
-
Vaccine [Vaccine] 2014 Feb 26; Vol. 32 (10), pp. 1192-8. Date of Electronic Publication: 2013 Sep 07. - Publication Year :
- 2014
-
Abstract
- To investigate susceptibility to and factors associated with rubella infection among pregnant mothers and to estimate the burden of congenital rubella infection (CRI) in Vietnam where rubella-containing vaccine (RCV) is not included in the routine immunization program, we conducted a prospective cohort study in Nha Trang, Vietnam between 2009 and 2010. Rubella-specific immunoglobulin-M and immunoglobulin-G were investigated in cord blood samples by enzyme immunoassay. Corresponding clinical-epidemiological data were analyzed and the national congenital rubella syndrome (CRS) incidence was estimated using modeling. We enrolled 1988 pairs of mothers aged 17-45 years and their newborn babies. No mothers had received RCV. Multivariate analysis revealed that mothers aged 17-24 (aOR 2.5, 95% CI: 1.7-3.8) or 25-34 (1.4, 1.0-2.1) years were more likely to be susceptible than those aged 35-45 years. Overall 28.9% (574/1988, 95% CI: 26.9-30.9%) of mothers were seronegative. The CRI rate was 151 (95% CI: 0-322) per 100,000 live births. Modeling estimated that 3788 babies (95% CI: 3283-4143) were born with CRS annually in Vietnam with an overall CRS incidence of 234 (95% CI: 207-262) cases per 100,000 live births. A substantial proportion of women of childbearing age (WCBA) are at risk of rubella infection during pregnancy and this can result in a high frequency of miscarriage or burden of CRS across Vietnam. Prompt introduction of RCV into national immunization program with catch-up vaccination to children and WCBA will reduce CRI in Vietnam.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Antibodies, Viral blood
Female
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Incidence
Infant, Newborn
Middle Aged
Models, Biological
Pregnancy
Prospective Studies
Rubella epidemiology
Rubella Vaccine administration & dosage
Seroepidemiologic Studies
Vietnam epidemiology
Young Adult
Fetal Blood virology
Pregnancy Complications, Infectious epidemiology
Rubella Syndrome, Congenital epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 24021315
- Full Text :
- https://doi.org/10.1016/j.vaccine.2013.08.076